Peptidomimetics to inhibit the SLIT2-ROBO1 interaction as a gateway to attenuate pancreatic adenocarcinoma (#137)
Mohsen Hosseini
1
,
Selina Mader
2
,
Nicolo Bisi
1
,
Ilyana Gonzales
1
,
Charlie Hollanders
1
,
Wim Versées
3
,
Ilse Rooman
2
,
Steven Ballet
1
- Research group of organic chemistry-ORGC, Vrije Universiteit Brussel, Brussels, Belgium
- Laboratory for Medical and Molecular Oncology, Vrije Universiteit Brussel, Brussels, Belgium
- Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium
Publish consent withheld
- 1. Rahib, L. et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74, 2913–2921 (2014).
- 2. Pinho, A.V et al. ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling. Nat Commun. 9, 5083 (2018).
- 3. Morlot, C. et al. Structural insights into the Slit-Robo complex. PNAS. 104 (38) 14923-14928 (2007).