Tuesday, 14th October The 16th Australian Peptide Conference 2025

• Die hard: cell explosion by pyroptosis escalates immune responses - Kate Schroder
• Peptide-Guided Late-Stage Diversification of BODIPY Probes for Selective Targeting of Aβ 1-42 Early Oligomers   - Nicolo Tonali
• Antibody-Drug-Conjugates (ADCs) for Block of HIV Entry - Hirokazu Tamamura
• Using cryo-electron microscopy to understand the biology and drug binding of the Wnt signalling pathway - Alisa Glukhova
• Selective chemical transformation via amyloid-substrate complex - Taka Sawazaki
• New Technologies for Accessing Modified Proteins - Richard Payne

• Helical peptide inhibitors that covalently bond to the oncogenic protein cMyc - David P Fairlie
• Peptides in tiny droplets: high-throughput peptide discovery with a twist - Conan Wang
• Ultrashort peptide sequence engineering for pharmaceutical nanomaterials - Celine Valery
• Novel multiplex combinatorial screening method based on the use of nanohydrogels, for discovering tumor targeting synthetic molecules. - Gerardo Byk
• Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors - Richard J Clark
• Marine-inspired antimicrobial peptides disrupting DNA-encoded gene expression - Luisa Beyer

Advancing Peptide Science: Deep Sequence Coverage and High-Throughput Peptide & Immunopeptidome Analysis with Orbitrap Excedion Pro, MX and Stellar mass spectrometry

Speakers:

• Dr. Maz Ali, Field Application Scientist, Thermo Fisher Scientific
• Scott Daltonalomes, Product Specialist- Material Science, Thermo Fisher Scientific

• Design and Synthesis of Insulin and Relaxin-Like Peptides and Analogues - M. Akhter Hossain
• Chemical Synthesis and Characterisation of the Structurally and Functionally Unique Peptide Natural Product Recifin A - K. Johan Rosengren
• Glycoconjugation with N-glycans improves drug properties of existing peptides and proteins - Yuji Nishiuchi
• Total synthesis of the antifungal and antiviral cyclic lipodepsipeptides verlamelins A and B - Urawadee Rajchakit
• Development of tCAP reagents for the site-specific modification of native IgG antibodies - Taku Yoshiya

• Total Chemical Synthesis of a 92-amino acid target-binding monobody via Cysteine-Free Folding-Assisted Ligation - Tim Reichart
• Breaking barriers in peptide therapeutics: hydrocarbon stapling of Temporin-FL peptide for improved bacterial membrane disruption - Vinutha A S
• β-Sheet Stapling: The Role of Structural Rigidity in Enhancing Antimicrobial Peptides Efficacy - Mikolaj Sleziak
• Development of Bitopic Ion Channel Ligands As Next Generation Pain Therapies - Harrison YR Madge
• From Peptides to Bioassays: Sustainable Preparation of PEGA Resins for the Next Generation of Chemical Biology - Mads Liep Ramsing
• Total Synthesis of Talarolide A Highlights the Role of Hydroxamates in Atropisomerism of Cyclic Peptides - Waleed M Hussein
• Systematic Mutagenesis Identifies Key Residues That Improve the Long-Term Stability and Bioactivity of Cyclotide Kalata B1 - Yen-Hua Crystal Huang
• Discovery of novel scaffolds targeting RXFP3/4 signaling system - Predrag Kalaba
• Melanocortin 5 Receptor Agonists as an Adjunct to Insulin Therapy in Diabetes   - Nicholas Barlow
• Gramicidin S and gramicidin C: Structurally unrelated but functionally comparable membranotropic peptides acting through distinct mechanisms of membrane disruption - Sergii Afonin
• Discovery of Selective Cyclic D-Sulfopeptide Ligands of the Chemokine CCL22 via Mirror-Image mRNA Display with Genetic Reprogramming - Belinda B. Zhang

• Controlling Thermodynamic Stability and Folding of Collagen Triple Helices by Strategic Dual N and C_α Substitution - Debashree Borah
• SAR studies of disulfide linked melanocortin peptides - Philibert Adriaan
• Evaluating Kv1.3-Selective Inhibitor Activity Across Kv1.3/Kv1.x Heterotetramers: Electrophysiological Characterisation and Structural Modelling - Yuandi Hu
• Development of Selective Melanocortin Receptor Ligands via a Novel Constrained Cyclic Peptide Scaffold - Junhan Zhu
• Bioengineered peptide-graphene nanoconjugates: A multifunctional strategy for broad-spectrum antimicrobial intervention - Shubhi Dr. Joshi
• Pharmacological Studies of Novel Constrained Melanocortin Peptides. - Li Jia
• Combinatorial Design of Orally Bioavailable Cyclic Peptides Targeting Somatostatin Receptor 2 - Mindi Li
•  Single molecule observation reveals the target search mechanisms of AP1 proteins on DNA tightropes - Neil Kad
• Modular total synthesis and antimycobacterial activity of rufomycins - Bryton Forster
• Tackling Heart Failure: On the Development of Potent Long-Acting UT-II-Derived Biogels - Thibault Cauwenbergh
• Introducing Regioselective Disulfide Linkages in Peptides under Pseudodilute Conditions by Harnessing Brønsted Acid-Activated N‑Chlorosuccinimide - Nitesh Mani Tripathi
• Computational modelling and AI predictions of conotoxins targeting HCN channels as a drug target for neuropathic pain - Deklanji Dissanayake
• Characterisation of the Skin Mucus Proteome in Barramundi (Lates calcarifer): Insights into Sex differentiation and Immunity in Fish - Varsha V Balu
• Building with precision - innovative tools in peptide synthesis - Karin Rustler
• Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus - Yoshimi Peck
• Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles - Minghao Shang
• Harnessing nature’s green pharmacy: exploring plant peptides with therapeutic potential - Antonio Sanchez Mc Sweeney
• Venoms to drugs: Elucidation of structure-function relationships in order to rationally optimise a venom-derived peptide for seizure control in KCNH1 epilepsy - Alexandra K Sundman
• Natural Peptides from Rhizomes - A Platform for Nutraceutical Innovation - Kruttika Purohit
• Elucidating the role of L-tyrosine in enhancing the antioxidant properties of β-Casein-derived peptides - Yasuri Amarasekara
• Enhancing Proteostasis in ALS through Novel Brain-Penetrating Peptides: A Therapeutic Approach Targeting Autophagy - Azin Amin
• Development of nanobodies targeting the relaxin receptor, RXFP1 - Tim Lkhagvajargal
• Targeting gastrointestinal biofilms with nature-derived antimicrobial peptides - Michael Michael
• Electrochemical Deprotection of Amino Groups: Advancing Sustainable Peptide Synthesis - Esteban Suárez-Picado
• Electrochemically enabled late-stage peptide backbone modifications - Saurabh Kumar Ahirwar
• Developing a machine learning model to predict peptide-ligand binding affinities to improve plasma protein purification - Elizabeth Phua
• Unleashing telomere maintenance toxicity in ALT cancers: A FANCM-RMI inhibiting bioactive peptide - Joshua Mills
• LYTAPs: cyclic peptides that induce lysosomal degradation of EGFR and overcome resistance in NSCLC and CRC - Quach Truong
• New Strategies for Electrochemical Peptide Modification - Dhanya Karipal Padinjare Veedu
• Cell penetrating peptides for the delivery of ASOs to the neural retina across rodents and NHP - Parvin Safari and Michael Hall
• Developing simplified insulin-like peptide 5 (INSL5) analogues as colon motility regulators - Hongkang Wu
• A greener orthogonal amine protecting strategy for SPPS - Jesse F.W. Wijaya
• Venom peptides to study heart function and treat cardiovascular diseases - Gabriel Osuna
• Recombinant production of an antimalarial peptide in Nicotiana benthamiana - Linh T.T. Nguyen
• Engineered Nanobodies Bind Bismuth, Indium and Gallium for Applications in Theranostics - Lani J Davies