Oral Presentation The 16th Australian Peptide Conference 2025

Oral Hepcidin Peptidomimetics to treat iron dysregulation (128956)

Greg T Bourne 1 , Roopa Taranath 2 , Ashok Bhandari 2 , Jie (Jenny) Zhang 1 , Jayanthi Vengalam 2 , Bo Yang 2 , Li Zhao 1
  1. Protagonist Therapeutics, Brisbane, Qld, Australia
  2. Protagonist Therapeutics, Newark, California, USA

Protagonist Therapeutics is at the forefront of developing peptide therapeutics across key areas, including inflammatory diseases, obesity, and iron regulation.
The subcutaneous hepcidin mimetic rusfertide offers a novel approach to managing chronic stress erythropoiesis. By mimicking the natural function of hepcidin, rusfertide regulates iron homeostasis through enhanced iron sequestration, providing a targeted therapeutic option for conditions such as polycythemia vera. This mechanism represents a compelling alternative to traditional treatments, which often have significant limitations.
This presentation will highlight Protagonist’s innovative strategies in developing next-generation peptide therapeutics, with a particular focus on iron regulation. These advancements have the potential to transform the treatment landscape and address critical unmet medical needs.